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UNMC researchers develop
fetal cell study alternatives -
OMAHA, Neb. (AP) —
University of Nebraska Medical
Center researchers have devel
oped some new alternatives to
replace aborted fetal tissue for
research in Alzheimer’s disease
and other degenerative brain
conditions.
However, researcners said
Wednesday they must continue
to use donated cells from elec
tive abortions until an alternative
source can be found to replace
fetal tissue for research in
Alzheimer’s disease and AIDS
related dementia.
The controversy over the use
of aborted fetal tissues erupted
last November when it was
reported that fetal brain cell tis
sue was being used in research at
the Medical Center.
The first successful recovery
procedure was conducted on pre
mature infants several weeks
ago. Other details were not avail
able due to confidentiality
requirements.
"The goal of this program is
to use alternatives to fetal tissue
cells as we are able,” said Dr.
Howard Gendelman, UNMC’s
chief researcher on degenerative
diseases of the brain.
Using the new research,
UNMC has been able to recover
astrocytes and microglia — two
of the three cells needed for the
w
^ The goal of this program is to use
alternatives to fetal tissue cells as
we are able.”
Dr. Howard Gendelman
UNMC researcher
research.
. So far, researchers have only
been able to recover mature neu
rons — the third and most
important research component
— from aborted fetuses.
The announcement did not
satisfy opponents of using abort
ed fetal tissue in the research.
"We don’t want to just see a
reduction in the amount of abort
ed babies used. We want to see
the whole thing end,” said Julie
Schmit-Albin, Executive
Director of Nebraska Right to
Life.
UNMC spent around
$250,000 to create a research
team, provide support staff and
provide new technology for the
project, Gendelman said.
The program required devel
opment of a protocol for gaining
family approval to recover the
cells. It also requires a team of
about a dozen researchers to be
assembled when the patient dies.
. The cells must be recovered
within two hours of death.
Adults could be used for tis
sue donation in the future, said
Dr. Susan Swindells, director of
UNMC’s HIV Clinic.
Swindells said that will
depend on the condition of
potential donors’ brain tissue,
which can be affected by disease.
Researcher Anuja Ghorpade
said scientists must use the same
type of tissue they are trying to
cure in their research.
Without mimicking human
disease as close as possible, it is
difficult to find the correct
answer,” Ghorpade said.
The University has sent its
protocol to the National Institute
of Health with applications for
$2 million in grants to continue
the program.
"We are encouraged. Not
only are we able to do it, we’ve
been able to do it rather quickly,”
Gendelman said.
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