page News Digests- Ne^kan L Qy Saturday, December 17,1988 __ ____ _________—..... — Historic American-PLO meeting held in Tunisia TUNIS, Tunisia ~ U S. Ambassa dor Robert H Pelletreau Jr. opened histone talks w ith the PLOon Friday, and both sides said they hoped the dialogue would lead to a comprehen sive Middle Fast peace. The meeting, coming just two days after Washington reversed a longstanding policy of refusing to deal with the PLO, inspired hope in many quarters that the Middle East peace process soon will become more than just an empty phrase. “Our discussions were very prac tical and characterized, I would say, by seriousness of purpose,” Pelle treau told reporters after the 90-min ute meeting with a four-man PLO delegation led by Yasser Abd-Rab bou, a member of the group’s execu tive committee. The ambassador implied there would be other meetings but did not say when. Abd-Rabbou said the next session probably would conic in the next few weeks. “It is our hope that this dialogue, as it develops, will help bring about direct negotiations that will lead to comprehensive peace,” said Pclle treau, who was accompanied to the talks by Edmund Hull, political coun selor at the U.S. Embassy in Tunis. Each side made separate state ments to reporters after the meeting at Dar Maghrcbia, an official Tunisian government guest residence in Carthage, a suburb just north of Tunis. Neither side gave substantive details of the talks. “We hope this dialogue will con tinue, and wc think it will continue, said Abd-Rabbou. “This beginning ol the dialogue shows that the whole world now is approaching the peace process with a more objective approach, and only the rulers of Israel arc insisting on a policy of arrogance and terrorism, and the continuation of the rejection of all United Nations resolutions,” he said. i Mai 5 wiiy wc iiupc uie applica tion of this change in the policy of the United States will be practiced though a real pressure on Israel in order to change the policy of occupa tion, the policy of terrorism, the pol icy of oppression against our Pales tinian people.” Since the announcement. Wednes day in Washington, the United States has emphasized that the new contacts arc merely a “dialogue” and do not represent real peace negotiations. Bush finally appoints Tower as national defense secretary WASHINGTON - President elect Bush Thursday named former Texas Sen. John Tower to be the nation’s next defense secretary, cap ping an extraordinary semi-public debate over the retired lawmaker’s personal and professional fitness for the post. In making the announcement be fore reporters, Bush hailed “my friend Sen. Tower” as a man of “great experience, expertise and commitment to peace and freedom.” He said the former lawmaker is com mitted to reforming the Pentagon. Tower thanked Bush for the ap pointment and said the nation must nave “as much if not more defense for less money.” He said that would require reforming the defense pur chasing system as well as installing biennial budgeting. He said both depended on close cooperation with Congress. Bush dodged but did not deny a question of whether he intends to appoint outgoing GOP Rep. Jack Kemp - a rival in the 1988 presiden tial campaign - to head the Depart ment of Housing and Urban Develop ment. Sources say that decision has been made, and that the incoming president also intends to make Chi cago transportation official Samuel Skinner his secretary of Transporta tion. Bush met on Thursday with Dr. Louis Sullivan, a medical school president and top contender to be come secretary of Health and Human Services and the first black in the Bush Cabinet. Willi Bush rushing to complete his Cabinet by the end of next week, sources also said Gary MacDougal, a Chicago business exocutive and Bush transition adviser, has emerged as a leading contender to be secretary of Labor. Tower has held a variety of sensi tive posts since leaving Congress, including as a negotiator in arms control talks with the Soviet Union and as head of a review board, popu larly known as the Tower Commis sion, appointed by President Reagan to probe the Iran-Contra affair. Bush made the announcement of Tower’s appointment in the custom ary style, at an appearance before reporters that quickly turned into a question-and-answer session. Asked about a possible meeting with Soviet leader Mikhail Gor bachev, Bush said, “There is no expectation that we will or won’t” have a summit session. “I don’t want to send out a signal that signals recal citrance or unwillingness to think anew or unwillingness to try to build upon progress,” he said. But he said he didn’t want to “send out the other signal ’ ’ and seem to be acting hastily. He said Gorbachev and other Soviet officials understand his view point. The president-elect said he r “wouldn’t overstate the impor tance’’ of the United States begin ning meetings with the Palestine Liberation Organization. He stressed that the Reagan administration has embarked on a dialogue and not a negotiation. As for Tower, some conservatives have complained that he is not a strong supporter of the proposed Stra tegic Defense Initiative, known as Star Wars. However, Bush said, “Senator Tower and I agree with... the position I look in the campaign, which is strong support for SDI.’’ Tower himself said the proposed system would not only be a useful deterrent to attack but also “a very valuable negotiating tool.’’ -1 inflation tears dampened Dy increase WASHINGTON -- Despite large November increases for gasoline and healing oil, wholesale prices con tinue to rise at an annual rate of less than 4 percent, the government said Friday, confounding predictions of a mounting inflation problem. Wholesale prices edged up just 0.3 percent in November as food costs at the wholesale level showed no in creases for the second straight month, the Labor Department said. The Novembe r increase, if it per sisted lor 12 months, would amount U> an annual inflation rate of just 3.3 percent, lower than the 3.K percent annual i/.cd rate for the first 11 months of 1987. “Inflationary fears exceed infla tionary reality at the present time,” said Donald Rataje/ak, director of economic forecasting at Georgia State University in Atlanta. Those fears were aggravated ear lier this week when the government reported that industrial production rose another half a percentage point in November and that factories were operating at a nine-year high of 84.2 percent of their capacity. Dirk Van Dongen. president of the National Association of Wholcsal crs-Distributors, said he sees no indi cation from the association’s 45,000 member companies that they arc building inventories in anticipation of future price spikes. Van Dongcn called the inflation ary fears a “manifestation of tribal rites in Washington and on the New York financial circuits” with the changing of presidential administra tions. “Let’s keep the debate a little bit honest,” he said. “I don’t see an inflationary psychology taking root, but Washington can talk itself into all sorts of things.” I wo experiments suggest cancer and brain disease treated by gene change WASHINGTON - Experiments in twoCalifomia laboratories suggest that genetically engineered cells may offer promise for suppressing the growth of some cancers and for cor recting hram disorders such as Alz heimer’s disease. The studies, in two dilfcrcnt labo ratories at the University of Califor nia, San Diego, involved the use of cells that were genetically altered and then injected or graded into labora tory animals, according to reports published Friday. In a study of cancer, Wen-Hwa Lee, a professor of pathology at UCSD, said a cancer-suppressing gene was insetted into the altered genetic pattern of a retrovirus, a type of virus that controls the genetic pat tern of a normal cell The retrovirus carrying the can cer-suppressing retinoblastoma gene, or RB, was then transplanted into cancer cells. To serve as a comparison, another type of gene, called luciferase, or LUX, was processed in the same way. Lee said both types of altered cancer cells then were injected into nude mice, a type of laboratory ro dent that lacks an immune system and is highly susceptible to developing cancer. Each of seven mice received both kinds of the altered cells, one type in each rear flank, he said. After a month, said Lee, the flanks injected with the LUX-infeeted cells developed tumors. No tumors, how ever, grew on the flanks that had 4 received ihe RB-infcctcd cells. Lee said il appears ihal ihe virus carrying ihe cancer-suppressing gene is able lo prevent ihe formation of malignant cells. Il suggests that this technique could be used to geneti cally convert malignant tumor cells, which grow very rapidly, to cells that grow normally, he said. “After the tumor cell received this virus,” said Lee, “the tumor cell would lose its malignancy. There fore, it would slop growing, or phase into a normal cell.” He said the technique using the RB gene theoretically could work in treatment of breast, bone and lung cancer, and a rare type of eye cancer in children. The absence of the RB gene has been linked to all these types of cancers. In another UCSD experiment, Theodore Friedmann, professor of pediatrics, said he and a group of researchers grafted genetically al tered cells into the brains of rats to produce a special protein called nerve growth factor that prevented damaged brain tissue from dying. Friedmann said the researchers disarmed a retrovirus by removing part of its genetic pattern. A gene that carries instructions for the production of nerve growth factor was then put into the pattern of the retrovirus. Next, the team put the altered retrovirus into cells called fibrob lasts. These fibroblasts now had the genetic instructions for producing nerve growth factor. The scientists then made surgical lesions in the brains of 16 rats, cutting the connection between the forebrain and the hippocampus. Normally, this would cause the degeneration of cholinergic cells, a type of brain tis sue that requires the nourishment of nerve growth factor. Eight of the rats received brain grafts containing fibroblasts altered to produce nerve growth factor. The other rats received grafts of unaltered fibroblasts. After two weeks, both groups of rats were killed and autopsicd. Friedmann said the rats that re ceived the unaltered fibroblasts expe rienced a loss of S1 percent of their cholinergic cells. But the rats that had received the fibroblasts carrying the nerve growth factor gene lost only 8 percent of their cholinergic cells. “The result is that cells that were destined to degenerate and die and disappear because of theinjury did not degenerate and die and disap pear,” the scientist said. * ‘They were spared by the presence of the cells producing nerve growth factor.” Among the disorders that may one day benefit from this type of therapy, he said, are Alzheimer’s disease, some types of mental retardation and cerebral palsy, and genetically based degeneration diseases. Both studies are published Friday 1h Science, the journal of the Ameri can Association for the Advancement of Science.." |cmE.CT CAU II f^ROtA NWAfcNI* , li Vsj\\,v SO^ Armenians can now call U.b. MORRIS TOWNSHIP, N.J. - Armenians can now make collect phone calls to the United Slates for the first time, under an agreement reached between the American Telephone & Telegraph Co. and Soviet authorities. In a statement Thursday, the company said the agreement cov ers only the Armenian Republic, which has spent the past 10 days digging out from a devastating earthquake. “This is the first agreement of its kind between AT&T and the Soviet Union, and marks a dra matic lessening of restrictions for Soviet citizens seeking to call the United States,” the company said. The volume of calls to and from the Soviet Union rose to eight times the normal level following the Dee. 7 quake, said Rick Mat thews, spokesman for Morris Township-based AT&T Interna tional. AT&T said it is also sending 10 facsimile machine? to Armenia to help rescue teams coordinate relief plans with organizations around the world. 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