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GERMS 01T DISEASES.
They Are Now Eoing Harnessed by
Medical Investigators.
Horr Tincllll Arc IkoIiiIciI, TckIciI mul
l'i'o)iiKnttil Important I'ui't
l'liiyoil ly Ilornrii unit
Uiilncxi I'Iuh,
Special New York Lottor.l
.CTpMIIS Is essentially 1 he nge of an
i J titoxliis, extreme ciiHi'H of the
"linlr of the (Joy" curing the
bite. Svw (Jlseovi'rJeH ure constantly
being fiiade, both of the Hpeellle
germs causing eertnln diseases anil
methods of utilizing tliem for Iheir
own destriiellon. Jt Is well known
thai If u person were shut up In u
room for uti extended length of time
where no fresh air wus allowed
lo enter death would ensue be
cause the air in the room, breathed
over and over, would become charged
with poisons given out by the body,
TESTING ANTI-TOXIN HOUSE.
nml there would soon be no fresh nir
to feed upon. Jn the ease of a dis
ease germ niueh tho same condition
prevails. It must have fresh material
to food upon, as the juices it throws
off arc a certain poison to itself.
Hence, if to tho blood of u person
containing germs of u disease, a suftl
eient quantity of the effete material
furnished by tho germ itself be
added, the small pest dies because it
lias no fresh food, free from its own
specific poison, upon w.hlch to feed.
In the ease of many of our most com
mon and virulent diseases the bacil
lus lias been Isolated and for their
treatment mi antitoxin linn been se
cured. Nearly everyone is aware thnt the
antitoxins in general use are ob
tained from horses, and tho methods
of scouring them are being constant
ly Improved upon. Of course the first
thing to bo considered is the isola
tion of tho offending microbe from
the thousands of different variety
which surround it. This presupposes
the fact that the wicked one is so
well known as to be recognizable;
that his portrait hangs in the germ
rogues' gallery.
After tho bacteria are removed
from a sufferer, they nre more care
fully cultivated thnn most plants, the
nsual medium being bouillon prepnrcd
from filtered, sterilized water and
fresh beef. After Btnnding for n few
hours, the bouillon la straiued, rcfll
tercd and resterllized. For several
clays, a process of reboiling, steriliz
ing and filtering goea on in white
dust-proof closets, by men dressed in
most immaeulnto white. It is kept in
Hterilized jura, stopped with sterilized
cotton. When this bouillon has bo
come absolutely free from all germs,
INOCULATING GUINEA PIG.
It Is inoculated by hnving the bacilli
dropped in from tho point of a needle
of glass and platinum. The germs
multiply as vapidly as in a human
'Jjody, for tho bouillon Is kept in n
warm incubator for ubout 7SJ hours,
-when it may be seen to bo covered
with a ghastly-looking, greenish
crust, a toxin which is a hideous mass
of the disease to be treated, consump
tion, diphtheria or whatever has been
:cultivated. It Is then injected into
iguinen pigs which die and are opened
nnd examined. If it is found that the
toxin wud pure, it is injected into an
untltoxin horse, llefore one of these
horses is utilized for this purpose,
he is tested to ascertain if he be free
irotu all disease, by receiving an in
jection of mallein, a fluid which will
vtrouso into .activity any disease
which may happen to lurk in his
W'Jll I J II
sj'stnn. Jf he be healthy, the mallein
will not affect him. llelng proven
healthy, the first injection of toxin,
about one-half a thimbleful, or one
cubic centimeter, is introduced into
ills blood from :i syringe of glass and
silver by a thoroughly sterilized, dlsin
fected, white-clad, (denn-aliaven physi
clan, in u white enameled stable. Tor
three days, the horse is very ill, eat
ing nothing. His bones are sore. Ho
swells, then slowly recovers. In ten
days, he Is quite well again, when an
other injection is given, this time of
three cubic centimeters. Ho becomes
ill, but less so than in the first in
stance. Ten days later, 20 cubic
centimeters are administered. Tho
effect of this is hardly perceptible.
liy the end of two months, more than
one pint or 600 cubic Centimeters ure
given without producing any ill-ef-fects.
This dose would kill a large
number of ordinary horhos, but our
friend bus become immune, that is,
his system is able to resist any num
ber of live germ:i introduced, because
It contains so much of their own
poison, that they have nothing to
feed upon and die from an overdose
of themselves.
Now that this antitoxin quality ha9
developed in the animal, each month
eight quarts of blood are drawn from
him, while every ten days he still re
ceives an injection of 500 centimeters
of toxin. Thus his antitoxic power U
kept up. He suffers no inconvenience.
His health is good, he exercises mod
erately and eats his sterilized grain
with relish. If lie goes to pasture for
a month or two, his antitoxic power
is impaired and he hns to begin all
over again with his first dose of one
cubic centimeter of toxin which ren
ders him ill as at first. After being
drawn from the horse, the blood is
sealed up and stands for several days,
when the serum, "or thin portion, is
extracted by menus of a force pump.
This serum is used on guinea pigs
and its strength thus ascertained. It
is now filtered and purified, sealed in
small vials and passes into the hand
of physicians In .general practice,
who Introduce it into the circulation
of such patients as nre suffering from
the special disease from whose germ
it was prepared. Their systems are
thus reen forced by a poison to tho
germs whose demise rids them of the
disease which was preying upon their
tissues.
While some antitoxins have been
obtained with comparative ease, ex
periments with typhoid germs have
proven very unsatisfactory. In 1SS1
Koch discovered the bacilli of ty
phoid. They are rod-like and thick
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FREEZING GERMS IN LIQUID AIR.
with the ends rounded, and .some
times joined in filaments. They pos
sess little hair-like projections called
llagella and move vory rapidly. They
are found in water, milk and meats
and gain ontniHce into the system by
various methods. Many experiments
huvo been mode to secure an antitox
in from bouillon, but to nogri-at pur
pose. Jt has been nearly impossible
to obtain, the "juice between tho
cells" of typhoid bacteria without de
stroying the chemical action of
germs themselves. No really satis
factory results had been obtained
until, recently, Dr. Allan MeKaydun,
of the .leaner institute of preventive
medicine, one of tho leading bac
teriologists of Europe, after much
research, has discovered a method of
manufacturing antitoxin for typhoid
which, It is generally believed, will
soon bo universally adopted. Tho
microscopical cellu of the typhoid
bacilli are so small and pliable or
elastic that no mechanical ugont
could destroy them. Freezing docs
not injure them.
It occurred to Dr. McFaydcn to
freeze the cells by means of liquid
uir until very brittle, then to crush
thoiiMindH of them together in a mor
tar. This first and most dlflieult
step has proved a great success. Tho
mass now dead, so far as its power of
communicating disease is concerned,
Is allowed to become warm again,
and Is still chemically alive as to
its qualities from which antitoxin
may bo prepared. llopeatod injec
tions Into animals have produced a
serum, which, it is believed, will
prove elllcaclous. if is too soon after
its discovery for a large number of
experiments to hnvo demonstrated
its successful use",' but results so far
obtained are very promising.
' VILLARD C. APPLET-OX.
A llleh Cm loh.
'Leaving college, old man'.' Going
to marry and settle down?"
"No; I'm going to murry uud settle
up." Chappnrul.
jmji i r kfi ji Jniiffi .
SfiIS&SEK
t jMrw B-niftjwfr
AN HONEST STREAK.
Which I. oil (t .Man Clinrjuccil wlih
Thefl (o Tukc Iliiiiftclf to
the CulfiliooMC.
Humor makes ill nppenrance in queer
places, but one would hardly expect lo find
it nt the door of a house of correction,
wiys the Milwaukee Sentinel. An unfor
tunate fellow was recently taken before
a justice of tho peuec in Milwaukee,
clmigcd with stealing n quantity of wood.
Tlicic wns not much of a defense to offer,
but an attorney who knew him volun
teered to say a few woids to the court
in his behalf.
The attorney began his talk, nnd, warm
ing up to his subject ns he proceeded,
finally miccccdcd in making a good pica for
leniency. The justice, of course, found
the prisoner guilty, but let him off with
a sentence of 150 (fays in the house of cor
rection. When the commitment had been
made out it was discovered that there was
no constable present, so the lawyer said
to the prisoner:
".John, you know where the houso of
correction is. don't you?"
"Yes, sir.
"Well, hero's five cents and this pnper.
You take a ear and go out there and give
them this paper and they'll let you m.
Will you do it?"
"Sure!"
And the funny part of this story is that
John kept his word.
ESTIMATING EACH OTHER.
SlicnvliiK Opinlniifi nn Tln'jr Mny Do
Koriued from Different
Point of View.
"My word, Fitznoodlc," said a war of
fice clerk, according to the London Ex
press, to a colleague who sat a! the next
dck, "just look uU that workman on the
roof of thut budding over the way!"
"What's the matter with him?' in
quired Fitz, glancing through the window
at the individual indicated.
"Matter," retorted the other; "why,
I've been watching the lay beggar for the
last Z'i minutes, and lie hasa t done a
Htroko of work all the time."
At the precise moment at which i the
above conversation occurred a Uritish
workingman was addressing his "mate."
"Sy, Hill," he remarked, in a tone of
deep disgust, "d'ye see that 'ere loafin' war
office chirk in that room darn there?
S'elp me, if Hi ain't bin watcliin' 'im fur
nigh on nrf an hower, an' the bloomer's
done nothin' but stare liouot o' th' win
der the 'ole blessed tyme. That's tho
Bort of chap as we pyc taxes tcr keep!"
m
A Cure for DrojiHy.
Sedgwick, Ark., June 22d.-Mr. W. S.
inylor of tins place says:
"My little boy had Dropsy. Two doc
tors tho best in this part of the country
told me he would never get better, nnd
tot have seen him anyone else would hnvo
said they were right. Hi feet and limbs
were swollen so that he could not walk
nor put on his bIiocs.
"When the doctors told me he would
surely die, 1 stopped giving him their med
icine and began giving him Dodd's. Kidney
Tills. I gave him three pills a day and at
the end of eight days the swelling was all
gone, hut as 1 wanted to he sure, 1 kept on
with the pills for some time, gradually re
ducing the quantity, till finally 1 stopped
altogether.
"Dodd's Kidney Pills certainly saved my
child s hie. llcfore using them he wns
a helpless invalid in his mother's arms
from morning till night. Now he is a
healthy, happy child, running and dancing
nnd singing. I can ncvci1 express our
gratitude.
"Dodd's Kidney Pills entirely cured our
boy after everybody, doctors and all. had
given him up to die."
A Wlilu-Sitreutl Vanity.
In these days there ricem to he as many
writers as there are readers. The spread
of authorship nnd its egregious pride is
hit off in this dialogue from the Flic
gende Ulnetter:
A guest at n hotel tnblc, reading the bill
of faro, says: "Your bill of fare is great!"
"I am glad to hear it," replies the head
waiter. "1 am its author."
A IIiir of Gold
has immeasurable attraction for anyone.
Let us send you attractive "Katy" pub
lications which will interest you. "The
Golden Square," "Timely lopics," "Old
Mexico," and nthcis. Free for the asking.
Address, "KATY," 512 Wainwright llldg.,
St. Louis, Mo.
Pitfalls in Vanity Fair. Edgar "Arthur
won't accept an invitation unless he
knows who is to be there." Edmund
"Maybe he's afraid ho will meet some of
his creditors." Brooklyn Life.
It Cure While You "Walk.
Allen's Foot-Ease is a certain cure for hot,
sweating, callus, and swollen, aching feet.
Sold by nil Druggists. Price 25c. Don't ac
cent nny substitute. Trial package FREE.
Address Allen S. Olmsted, Le Hoy, N. Y.
i
Arrogance is always the sign of a little
and unoenevolent temper, having no more
greatness in it than the swelling of the
dropsy. Collier.
To Cure n Colo" In One Day.
Take Laxative Tlromo Quinine Tablets. All
druggists refund moneyifitfailsto cure. 25c.
He (gloomily) "Do you know how much
the luncheon you have ordered will cost?"
She "No, don't tako away my appetite!"
Town Topics.
''
f nm sure Plso's Cure for Consumption
snved my life three years ago. Mrs. Thos,
Robbins, Norwich, N. Y Feb. 17,1900.
- !
A laugh is worth n hundred groans in
nny market. Chicago Journal.
... in... ' -
Cab drivers' lives are filled with whoa.
Chicngo Daily News.
Pommel
KEEPTHCRIDEn DflY
Utln on't cl t Ui man b
w,-ir. Huwrtr'i Oiled
Ulottilnir. Hijrlcitoiutt til
pccupauoni. umn
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rcniiiiio.
UUCfU t rrp
llicni. wrltn
forcuUlojua
II.X.9mr
A Son, BoleJlfr.
rt Caubrldf , Rait.
SAWYER'S
HEXCELSIOR BRAND
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Mrs. Hughson,
J.YAJ.O. ULUiiliOUll) KJL KliLclU W11U5C M
letter follows, is another woman in high
position who owes her health to the use of
Lydia E Pinkham's Vegetable Compound
"Dra.ii Mns. Pikknam: I suffered for several years with general
weakness and bearing-down pains, caused by womb trouble. Iy appe
tite was fitful, and I would lie awalte for hours, and could not sleep,
until I seemed more weary in tho morning than when I retired. After
reading one of jrour advertisements I decided to try tho merits of !Lydia
ID. Pinkham's Vegetablo Compound, and I am so glad I did. !No ono
can describe tho good it did me. I took three bottles faithfully, and
besides building up my general health, it drove all disease and poison
out of my body, and made mo feel as spry and active as a young girl.
Mrs. Pinkham's medicines are certainly all they are claimed to be."
Mns. M. E. IIuausoK, 347 East Ohio St., Chicago, 111.
Mrs. Pinlchnm Tells How Ordinary Tasks Produce Displacements.
Appai-cntly trifling" incidents in woman's daily life frequently produce
displacements of the womb. A Glip on the btairs, lifting during- menstruation,
standing" at a counter, running' a sewing1 machine, or attending to the most
ordinary tasks may result in displacement, and a train of serious evils is started.
The first indication of such trouble should be tho signal for quick action.
Don't let tho condition becomo chronic through neglect or a mistaken idea
that j'ou can overcome it by exercise or leaving it alone.
Moro than a million women have regained health by the use of Lydia E.
Pinkham's Vegetable Compound.
If the slightest trouble appears which you do not understand
write to Mrs. Pinkliam, at Iyim, Mass., for her advice, and a few
timely words from her will show you tho right thing to do. This
advice costs you nothing, but it may mean life or happiness or both.
trCTE Jt
Compound
health to women who
tho worst forms of female complaints, that bearing-down feeling, weak
back, falling and displacement of the womb, inflammation of the ovaries, and
all troubles of the uterus or womb. It dissolves and expels tumors from tho
uterus in the early stage of development, and checks nny tendency to cancer
ous humors. It subdues excitability, nervous prostration, and tones ip tho
entire female system. Its record of cures is the greatest in the world, and
should bo relied upon with confidence.
VELfinn FORFEIT If wo ennnot forthwith nrndnro the orlRlnallottnrs find (signatures of
tRalllllll al)vo testimonials, which -will prove their nbsoliitu L'oMUlnoiie.s.
WUWUU LyUlu K. l'inkhum Mctllciuo Co., Lynn, Muu.
"FOLLOW
rw
Only Double Daily Sleeping Car
Line to BOSTON.
THE WABASH LINE,
In connection with the West Shore and Boston &
Maine Railroads, has inaugurated double daily serv
ice between St. Louis and Boston.
Lvavltiy &t. LoiiIh w.Ott A. .V. -S::io . M.
Arrlvtnu Huston r,:tiO 1'. V,-;.;u A. Jt.
Arriving Xew York Sts'.to i JI.-7:t) A. Jt.
Additional Train, via Wabash and Del., Lack. & Western.
j.cuvvb st. Xohm ji::ue J', jr,
Arrlvt'H Xinv York 7:-IS A. 31.
Arrive lloston Uiiio A. J7.
All above trains curry throuch Sleeping Cars to Now Yorlc City and aro convenient
for passenger to Toledo, Dotrolt, Niagara Falls and Hutlalo. '
For full information regarding Butnmer tour tickets via theso trains to all Kastorn
resorts call at
Ticket Office, Olive and Eighth Streets, N. E. Cor.
i
J KQKn
m'TttrsTBVAiiirnjaa
of Chicago, whose
Mrs. Lelah Stowell, 177 Wellington
St., Kingston, Ont., writes:
"DnATi Mns. f Pinkiiam : You are indeed a.
godsend to women, and if they all knew what;
you could do for them, there would bo no need,
of their dragging out miserable lives in agony.
"I suffered for years with bearing-down pains,
womb trouble, nervousness, and excruciating head
ache, but a feAV bottles of Lydia E. Pinkham's
vegetable Compound made me iook
new and promising to me. I am light and
happy, and I do not know what sickness
is, and I now enjoy the best of health."
Lydia E. Pinkham's Vegetable
can always be relied upon to restoro
thus suffer. It is a sovereign cure for
THE FLAG.
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